placental transfer of respiratory syncytial virus-specific igg in iranian mothers

Authors

mehrnoosh doroudchi

department of immunology hamidreza dehshiri

department of biology, islamic azad university, jahrom alamtaj samsami dehaghani

department of obstetrics and gynecology, shiraz university of medical sciences, shiraz, iran

abstract

background: respiratory syncytical virus infection is the most common cause of bronchiolitis and viral pneumonia in infancy. objective: to investigate the placental transfer of rsv-specific igg in iranian mothers. methods: the antibodies were measured in sera of 146 mother/newborn pairs using a commercially available indirect enzyme linked immunosorbent assay (elisa). the studied subjects were among healthy pregnant women who attended to the zeinabieh hospital of shiraz university of medical sciences in a one year period. results: a highly significant correlation was observed between rsv-specific igg in newborns and mothers (r = 0.88). however, mean rsv-specific igg antibodies in neonates was significantly higher than that of their mothers (p = 0.019). in addition, the mean cord/maternal ratio of rsv-specific igg was detected to be 1.27 ± 0.60. maternal blood group, age, parity, previous abortions and neonatal gestational age had no correlation with placental transfer of rsv-specific igg antibodies. conclusion: our finding demonstrates that placental transfer of rsv-specific igg antibodies is an active process and the main factor that influences this transfer is maternal concentration of these immunoglobulins.

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Journal title:
iranian journal of immunology

جلد ۱، شماره ۳، صفحات ۱۸۳-۱۸۸

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